臭氧治疗联合常规治疗对 COVID-19 患者死亡率的影响。
Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19.
机构信息
Haydarpaşa Numune Training and Research Hospital, Department of Emergency Medicine, University of Health Sciences, Istanbul, Turkey.
Kosuyolu Rezonans Clinic, Integrative Medicine, Istanbul, Turkey.
出版信息
Int J Clin Pract. 2021 Aug;75(8):e14321. doi: 10.1111/ijcp.14321. Epub 2021 May 24.
AIM
In this study, we aimed to investigate the effectiveness of ozone therapy, which is one of the integrative medicine applications that has been used safely for many years, on the prevalence of mortality in patients receiving COVID-19 treatment.
METHODS
This was a prospective, controlled study conducted on patients with COVID-19 who were hospitalised. In this study, 55 patients were included. The patients were divided into two groups as the ozone and control group. Ozone therapy (major autohemotherapy) was applied to 37 patients who were being treated with the appropriate COVID-19 treatment protocol determined by the infectious diseases committee of our hospital. The ozone treatment protocol consisted of seven sessions (one session per day) of intravenous ozone administration, applied in a volume of 100 mL and a concentration of 30 μg/mL. Only the conventional COVID-19 treatment protocol was applied to 18 patients in the control group. Clinical follow-up was performed until the discharge of the patients from the hospital with successful treatment or until the mortality occurred. Factors affecting mortality were analysed using univariate regression analysis.
RESULTS
Intensive care unit (ICU) hospitalisation was required in 6 of the 37 patients who were treated with ozone (16.2%), while 4 of 18 patients in the control group required ICU treatment (22.2%) (P = .713). When the mortality rates between the two groups were compared, mortality was lower in the ozone group (P = .032). As a result of univariate logistic regression analysis performed to investigate the factors affecting mortality, treatment with ozone therapy was determined as a risk factor for mortality. Patients receiving ozone therapy appear to have a lower mortality risk (odds ratio [OR]: 0.149, 95% confidence interval [CI] 0.026-0.863, P = .034).
CONCLUSION
In this study, the findings suggested that the administration of ozone therapy along with the conventional medical treatment in patients hospitalised for COVID-19 could reduce mortality.
目的
本研究旨在探讨臭氧疗法的有效性，臭氧疗法是一种已安全应用多年的整合医学应用之一，其对接受 COVID-19 治疗的患者的死亡率的影响。
方法
这是一项针对住院 COVID-19 患者的前瞻性、对照研究。本研究纳入了 55 名患者。患者分为臭氧组和对照组两组。对 37 名接受我院传染病委员会确定的适当 COVID-19 治疗方案的患者应用臭氧治疗（主要自体血疗法）。臭氧治疗方案包括静脉内臭氧给药七次（每天一次），剂量为 100ml，浓度为 30μg/ml。对照组 18 名患者仅接受常规 COVID-19 治疗方案。对患者进行临床随访，直至成功治疗出院或死亡。使用单因素回归分析来分析影响死亡率的因素。
结果
接受臭氧治疗的 37 名患者中有 6 名（16.2%）需要入住重症监护病房（ICU），而对照组 18 名患者中有 4 名（22.2%）需要入住 ICU（P=.713）。当比较两组的死亡率时，臭氧组的死亡率较低（P=.032）。为了研究影响死亡率的因素，对单因素逻辑回归分析进行了分析，结果表明臭氧治疗是死亡率的危险因素。接受臭氧治疗的患者死亡率较低（比值比[OR]：0.149，95%置信区间[CI] 0.026-0.863，P=.034）。
结论
本研究结果表明，在 COVID-19 住院患者中常规医学治疗的基础上联合臭氧治疗可降低死亡率。
Zotero 插件