Chirumbolo Salvatore, Varesi Angelica, Franzini Marianno, Valdenassi Luigi, Pandolfi Sergio, Tirelli Umberto, Esposito Ciro, Ricevuti Giovanni
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
Biomedicines. 2022 Sep 12;10(9):2258. doi: 10.3390/biomedicines10092258.
An increasing body of evidence in the literature is reporting the feasibility of using medical ozone as a possible alternative and adjuvant treatment for COVID-19 patients, significantly reducing hospitalization time, pro-inflammatory indicators, and coagulation markers and improving blood oxygenation parameters. In addition to the well-described ability of medical ozone in counteracting oxidative stress through the upregulation of the main anti-oxidant and scavenging enzymes, oxygen-ozone (O-O) therapy has also proved effective in reducing chronic inflammation and the occurrence of immune thrombosis, two key players involved in COVID-19 exacerbation and severity. As chronic inflammation and oxidative stress are also reported to be among the main drivers of the long sequelae of SARS-CoV2 infection, a rising number of studies is investigating the potential of O-O therapy to reduce and/or prevent the wide range of post-COVID (or PASC)-related disorders. This narrative review aims to describe the molecular mechanisms through which medical ozone acts, to summarize the clinical evidence on the use of O-O therapy as an alternative and adjuvant COVID-19 treatment, and to discuss the emerging potential of this approach in the context of PASC symptoms, thus offering new insights into effective and safe nonantiviral therapies for the fighting of this devastating pandemic.
文献中越来越多的证据表明，使用医用臭氧作为COVID-19患者可能的替代和辅助治疗方法具有可行性，可显著缩短住院时间、降低促炎指标和凝血标志物，并改善血液氧合参数。除了通过上调主要抗氧化和清除酶来对抗氧化应激这一已被充分描述的医用臭氧能力外，氧-臭氧（O-O）疗法在减轻慢性炎症和免疫血栓形成方面也已被证明是有效的，而慢性炎症和免疫血栓形成是导致COVID-19病情加重和严重程度的两个关键因素。由于慢性炎症和氧化应激也被认为是SARS-CoV2感染长期后遗症的主要驱动因素之一，越来越多的研究正在探讨O-O疗法在减少和/或预防广泛的COVID后（或PASC）相关疾病方面的潜力。本叙述性综述旨在描述医用臭氧发挥作用的分子机制，总结将O-O疗法用作COVID-19替代和辅助治疗的临床证据，并讨论这种方法在PASC症状背景下的新潜力，从而为对抗这一毁灭性大流行的有效和安全的非抗病毒疗法提供新见解。
