Flow Pharma, Inc., 4829 Galaxy Parkway, Suite K, Warrensville Heights, OH 44128, United States of America.
Department of Chemical and Systems Biology, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305, United States of America.
Infect Genet Evol. 2021 Sep;93:104897. doi: 10.1016/j.meegid.2021.104897. Epub 2021 May 7.
A mutation analysis of SARS-CoV-2 genomes collected around the world sorted by sequence, date, geographic location, and species has revealed a large number of variants from the initial reference sequence in Wuhan. This analysis also reveals that humans infected with SARS-CoV-2 have infected mink populations in the Netherlands, Denmark, United States, and Canada. In these animals, a small set of mutations in the spike protein receptor binding domain (RBD), often occurring in specific combinations, has transferred back into humans. The viral genomic mutations in minks observed in the Netherlands and Denmark show the potential for new mutations on the SARS-CoV-2 spike protein RBD to be introduced into humans by zoonotic transfer. Our data suggests that close attention to viral transfer from humans to farm animals and pets will be required to prevent build-up of a viral reservoir for potential future zoonotic transfer.
对世界各地按序列、日期、地理位置和物种收集的 SARS-CoV-2 基因组进行突变分析，揭示了与武汉初始参考序列相比大量的变异。该分析还表明，感染 SARS-CoV-2 的人类已将病毒传染给了荷兰、丹麦、美国和加拿大的水貂种群。在这些动物中，一小部分刺突蛋白受体结合域（RBD）的突变经常以特定组合出现，已重新转移到人类中。在荷兰和丹麦观察到的水貂中的病毒基因组突变表明，SARS-CoV-2 刺突蛋白 RBD 的新突变有可能通过人畜共患病传播转移到人类。我们的数据表明，需要密切关注病毒从人类向农场动物和宠物的转移，以防止为未来可能的人畜共患病传播而建立病毒库。
