Bi Zhenfei, Hong Weiqi, Yang Jingyun, Lu Shuaiyao, Peng Xiaozhong
Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu Sichuan China.
National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.
MedComm (2020). 2021 Nov 16;2(4):548-568. doi: 10.1002/mco2.98. eCollection 2021 Dec.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiology of coronavirus disease 2019 (COVID-19) pandemic. Current variants including , , , , and increase the capacity of infection and transmission of SARS-CoV-2, which might disable the in-used therapies and vaccines. The COVID-19 has now put an enormous strain on health care system all over the world. Therefore, the development of animal models that can capture characteristics and immune responses observed in COVID-19 patients is urgently needed. Appropriate models could accelerate the testing of therapeutic drugs and vaccines against SARS-CoV-2. In this review, we aim to summarize the current animal models for SARS-CoV-2 infection, including mice, hamsters, nonhuman primates, and ferrets, and discuss the details of transmission, pathology, and immunology induced by SARS-CoV-2 in these animal models. We hope this could throw light to the increased usefulness in fundamental studies of COVID-19 and the preclinical analysis of vaccines and therapeutic agents.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是2019冠状病毒病（COVID-19）大流行的病原体。目前的变种，包括 、 、 、 和 ，增加了SARS-CoV-2的感染和传播能力，这可能会使现有的治疗方法和疫苗失效。COVID-19目前给全球医疗系统带来了巨大压力。因此，迫切需要开发能够捕捉COVID-19患者所观察到的特征和免疫反应的动物模型。合适的模型可以加速针对SARS-CoV-2的治疗药物和疫苗的测试。在这篇综述中，我们旨在总结目前用于SARS-CoV-2感染的动物模型，包括小鼠、仓鼠、非人灵长类动物和雪貂，并讨论SARS-CoV-2在这些动物模型中引起的传播、病理学和免疫学细节。我们希望这能为COVID-19基础研究以及疫苗和治疗药物的临床前分析的实用性提升提供思路。
