Department of Otolaryngology, Linyi Central Hospital, Linyi, 276400 Shandong, China.
Clinical Laboratory, Linyi Central Hospital, Linyi, 276400 Shandong, China.
Pathol Res Pract. 2021 Jul;223:153460. doi: 10.1016/j.prp.2021.153460. Epub 2021 Apr 30.
Laryngeal squamous cell carcinoma (LSCC), is the second most common malignant cancer of the head and neck after oral cavity cancer. Laryngeal cancer is associated with huge socio-economic burden worldwide. Studies have widely explored the role of non-coding RNAs, especially microRNAs and long non-coding RNAs in pathogenesis of laryngeal cancer. In addition, several studies have explored the mechanism and function of circRNAs. CircRNAs has higher stability and more extensive function models, including combining miRNA as sponge, modifying transcription, and even regulating protein translation have been developed. Therefore, circRNAs is applied as an excellent diagnostic tool and a promising candidate for development of cancer therapies. This study reviews the biogenesis and function of circRNAs, explores potential mechanism of circRNAs in LSCC, and implications and challenges in LSCC research.
喉鳞状细胞癌（LSCC）是继口腔癌之后头颈部第二大常见的恶性肿瘤。喉癌在全球范围内与巨大的社会经济负担相关。研究广泛探索了非编码 RNA 的作用，特别是 microRNAs 和长非编码 RNA 在喉癌发病机制中的作用。此外，已有几项研究探索了 circRNAs 的机制和功能。circRNAs 具有更高的稳定性和更广泛的功能模式，包括作为 miRNA 的海绵、修饰转录，甚至调节蛋白质翻译等。因此，circRNAs 被用作一种优秀的诊断工具和癌症治疗开发的有前途的候选物。本研究综述了 circRNAs 的生物发生和功能，探讨了 circRNAs 在 LSCC 中的潜在机制，以及在 LSCC 研究中的意义和挑战。
