Sabatini Serena, Woods Robert T, Ukoumunne Obioha C, Ballard Clive, Collins Rachel, Clare Linda
College of Medicine and Health, University of Exeter, Exeter, UK.
Dementia Services Development Centre, School of Health Sciences, Bangor University, Bangor, UK.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2022 Sep;29(5):840-866. doi: 10.1080/13825585.2021.1923634. Epub 2021 May 11.
Research studies exploring the association of cognitive complaints with objectively assessed cognitive decline report inconsistent results. However, many of these have methodological limitations. We investigated whether 1) more severe subjective cognitive decline (SCD) and subjective memory decline (SMD) predict change in objectively assessed global cognition, remote memory, recent memory, learning; 2) the predictive value of more severe SMD over change in objectively assessed remote memory, recent memory, and learning is stronger for individuals that report an SMD that started within the past five years than for those that report an SMD that started five or more years previously and/or stronger for those that experienced SMD within the past two years than for those who had not; and 3) greater depression and anxiety are associated with more severe SCD and SMD. We used two-year longitudinal data from the CFAS-Wales study (N = 1,531; mean (SD) age = 73.0 (6.0) years). We fitted linear regression models. More severe SCD and SMD did not predict change in objectively assessed global cognition, remote memory, and recent memory but predicted lower scores in learning. The prediction of SMD over change in learning was not stronger when individuals reported an SMD that started within the past five years compared to when they reported an SMD that started five or more years previously nor when individuals reported an SMD that started within the past two years than those who did not. Greater depression and anxiety were associated with more severe SCD and SMD. More severe SMD may be useful for predicting lower learning ability and for identifying individuals experiencing depression and anxiety.
探索认知主诉与客观评估的认知衰退之间关联的研究报告结果并不一致。然而，其中许多研究存在方法学上的局限性。我们调查了：1）更严重的主观认知衰退（SCD）和主观记忆衰退（SMD）是否能预测客观评估的整体认知、远期记忆、近期记忆、学习能力的变化；2）对于报告过去五年内开始出现SMD的个体，与报告五年或更久之前开始出现SMD的个体相比，更严重的SMD对客观评估的远期记忆、近期记忆和学习能力变化的预测价值是否更强，以及/或者对于过去两年内经历过SMD的个体，与未经历过的个体相比，其预测价值是否更强；3）更严重的抑郁和焦虑是否与更严重的SCD和SMD相关。我们使用了来自威尔士认知功能与衰老研究（CFAS-Wales）的两年纵向数据（N = 1,531；平均（标准差）年龄 = 73.0（6.0）岁）。我们拟合了线性回归模型。更严重的SCD和SMD并不能预测客观评估的整体认知、远期记忆和近期记忆的变化，但能预测学习能力得分更低。当个体报告过去五年内开始出现的SMD时，与报告五年或更久之前开始出现的SMD相比，以及与未经历过SMD的个体相比，SMD对学习能力变化的预测并不更强。更严重的抑郁和焦虑与更严重的SCD和SMD相关。更严重的SMD可能有助于预测较低的学习能力，并识别出经历抑郁和焦虑的个体。
