College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, P. R. China.
Department of Minimally Invasive Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin Heilongjiang, P. R. China.
J Bioinform Comput Biol. 2021 Jun;19(3):2140004. doi: 10.1142/S0219720021400047. Epub 2021 May 11.
Glioma is one particular type of brain malignancy which is highly complex and usually has a poor prognosis. Despite the limited diagnostic level of glioma, the survival time of affected patients broadly varies. Here, we conducted a detailed analysis, regarding the differences in patient survival time, to discover potential survival-related genes in glioma as well as their putative regulatory mechanisms. To contextualize the acquisition of these potential prognosis markers in large populations, particularly in China, we combined CGGA and The Cancer Genome Atlas (TCGA) databases to properly identify genes that are significantly related to survival. Our workflow combined a series of analytical approaches, including differential analysis, survival time, co-expression, clinical correlation analysis, ROC curve evaluation and prediction ability. Our results indicate that the four particular genes - PLAT, IGFBP2, BCAT1, SERPINH1 could be used as independent prognostic marker genes. These genes have also shown good prognostic ability in distinct populations, reiterating the robustness and value of these prognostic markers.
神经胶质瘤是一种特定类型的脑恶性肿瘤，非常复杂，通常预后不良。尽管神经胶质瘤的诊断水平有限，但受影响患者的存活时间差异很大。在这里，我们进行了详细的分析，研究了患者存活时间的差异，以发现神经胶质瘤中与存活相关的潜在基因及其可能的调节机制。为了在大人群中获得这些潜在的预后标志物，特别是在中国，我们结合了 CGGA 和癌症基因组图谱（TCGA）数据库，以正确识别与生存显著相关的基因。我们的工作流程结合了一系列分析方法，包括差异分析、生存时间、共表达、临床相关性分析、ROC 曲线评估和预测能力。我们的结果表明，PLAT、IGFBP2、BCAT1 和 SERPINH1 这四个特定基因可以作为独立的预后标志物基因。这些基因在不同的人群中也表现出了良好的预后能力，再次验证了这些预后标志物的稳健性和价值。
