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胎儿生长受限的复发风险:后续妊娠的管理。

Recurrence Risk of Fetal Growth Restriction: Management of Subsequent Pregnancies.

机构信息

Maternal-Fetal Medicine, University of Utah Health, Intermountain Healthcare, 30 North 1900 East, 2A200, Salt Lake City, UT 84132, USA.

Maternal-Fetal Medicine, Intermountain Healthcare, University of Utah Health, 5121 South Cottonwood Street, Suite 100, Murray, UT 84107, USA. Electronic address: https://twitter.com/jess_m_page.

出版信息

Obstet Gynecol Clin North Am. 2021 Jun;48(2):419-436. doi: 10.1016/j.ogc.2021.03.002.

Abstract

Fetal growth restriction (FGR) is a common obstetric complication that predisposes to mortality across the lifespan. Women with a prior pregnancy affected by FGR have a 20% to 30% risk of recurrence, but effective preventive strategies are lacking. Pharmacologic interventions to prevent FGR are lacking. Low-dose aspirin may be somewhat effective, but low-molecular-weight heparin and sildenafil are not. Surveillance in a subsequent pregnancy may consist of serial ultrasonography with timing and frequency determined by the clinical severity in the index pregnancy. Once FGR is diagnosed, the principal management strategy consists of close surveillance and carefully timed delivery.

摘要

胎儿生长受限(FGR)是一种常见的产科并发症,可导致终生死亡率增加。曾患有 FGR 的妊娠女性有 20%至 30%的复发风险,但目前缺乏有效的预防策略。预防 FGR 的药物干预措施尚缺乏。小剂量阿司匹林可能有一定效果,但低分子量肝素和西地那非则无效。在后续妊娠中进行监测,可通过在指数妊娠中的临床严重程度确定时间和频率,进行系列超声检查。一旦诊断出 FGR,主要的管理策略包括密切监测和适时分娩。

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