癌症中免疫逃逸的转译控制。
Translational Control of Immune Evasion in Cancer.
机构信息
Department of Molecular Biology, University of Texas Southwestern (UTSW) Medical Center, Dallas, TX 75390, USA.
Department of Molecular Biology, University of Texas Southwestern (UTSW) Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, UTSW Medical Center, Dallas, TX 75390, USA.
出版信息
Trends Cancer. 2021 Jul;7(7):580-582. doi: 10.1016/j.trecan.2021.04.002. Epub 2021 May 7.
Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control of immune checkpoints and implications for cancer immunotherapies.
控制翻译的机制在肿瘤的进展和转移中起着重要作用。新出现的证据表明，翻译失调也会影响细胞或致癌应激下的免疫逃逸。在这里，我们总结了关于免疫检查点的翻译控制及其对癌症免疫治疗的意义的现有知识。
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