奥马环素对小鼠尿路感染模型中大肠杆菌的疗效。
Efficacy of Omadacycline against Escherichia coli in a Mouse Urinary Tract Infection Model.
机构信息
Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
UTHealth Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0026921. doi: 10.1128/AAC.00269-21.
Abstract
In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains.
摘要
在小鼠尿路感染模型中，与庆大霉素相比，奥马环素（OMC）对四环素敏感（TET-S）、环丙沙星耐药（CIP-R）大肠杆菌的疗效相当，优于环丙沙星（CIP）；而庆大霉素对 TET-R、CIP-R 大肠杆菌的疗效优于 OMC，OMC 对该菌株的疗效也优于环丙沙星。奥马环素可能是治疗 CIP-R 大肠杆菌尿路感染的一种潜在选择，值得进一步研究。
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