在泌尿道生理条件下，质粒基因赋予对环丙沙星的临床耐药性。
Plasmidic Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions.
作者信息
Martín-Gutiérrez Guillermo, Rodríguez-Martínez José Manuel, Pascual Álvaro, Rodríguez-Beltrán Jerónimo, Blázquez Jesús
机构信息
Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, Universidad de Sevilla, Sevilla, Spain.
Unidad Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, Spain.
出版信息
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02615-16. Print 2017 Apr.
Abstract
variants expressing plasmid-mediated genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.
摘要
通过标准药敏试验，表达质粒介导基因的变体通常对氟喹诺酮类药物敏感。在此我们表明，在特定的泌尿道生理条件下，携带相关决定因素的敏感实验室菌株和临床菌株会对环丙沙星（CIP）产生完全耐药性。因此，在针对治疗尿路感染（UTI）中的[相关病原体]进行CIP活性药敏试验以及为UTI治疗选择合适抗生素时，应考虑生理条件，主要是尿液pH值。
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