Bixler E O, Kales A, Vela-Bueno A, Niklaus D E, Shubert D D, Soldatos C R
Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey 17033.
Int J Neurosci. 1988 May;40(1-2):1-11. doi: 10.3109/00207458808985721.
Blood pressure and sleep-wakefulness patterns were monitored in the sleep laboratory over four consecutive nights in six patients with mild hypertension and six age- and sex-matched controls. In both hypertensives and normals, blood pressure levels decreased during sleep compared with presleep levels by 16.6 and 8.4%, respectively; levels for hypertensives, however, remained significantly above those for the normals. The nocturnal drop in blood pressure for both groups appeared to be related primarily to the general state of sleep rather than to any specific sleep stage. Nocturnal patterns of sleep stages and sleep cycling were almost identical for the two groups. Nocturnal blood pressure fluctuation was correlated positively with the distribution of nocturnal wakefulness in hypertensives but not in normotensives. This suggests that with hypertension there is some diminution of the dampening effect of sleep itself upon blood pressure which normally carries over into periods of nocturnal wakefulness. This alteration in patients with mild hypertension may reflect a decrease in the sensitivity of the baroreceptor reflex or some other pathophysiological process.
在睡眠实验室对6名轻度高血压患者和6名年龄及性别匹配的对照者连续4个晚上监测血压和睡眠-觉醒模式。在高血压患者和正常对照者中，睡眠期间的血压水平与睡前水平相比分别下降了16.6%和8.4%；然而，高血压患者的血压水平仍显著高于正常对照者。两组夜间血压下降似乎主要与睡眠的总体状态有关，而非与任何特定睡眠阶段有关。两组的睡眠阶段和睡眠周期的夜间模式几乎相同。高血压患者夜间血压波动与夜间觉醒分布呈正相关，而正常血压者则无此相关性。这表明高血压患者睡眠本身对血压的缓冲作用有所减弱，而这种作用通常会延续到夜间觉醒期。轻度高血压患者的这种改变可能反映了压力感受器反射敏感性降低或其他一些病理生理过程。
