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老年亚临床抑郁症患者皮质下结构的初步比较：3T磁共振成像的结构分析

Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI.

作者信息

Im SangJin, Lee Jeonghwan, Kim Siekyeong

机构信息

Lee Gil Ya Cancer & Diabetes Institute, Gachon University, Incheon 21999, Korea.

Department of Psychiatry, Chungbuk National University College of Medicine, Cheongju 28644, Korea.

出版信息

Exp Neurobiol. 2021 Apr 30;30(2):183-202. doi: 10.5607/en20056.

DOI:10.5607/en20056
PMID:33972469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8118753/
Abstract

Depression in the elderly population has shown increased likelihood of neurological disorders due to structural changes in the subcortical area. However, further investigation into depression related subcortical changes is needed due to mismatches in structural analysis results between studies as well as scarcities in research regarding subcortical connectivity patterns of subclinical depression populations. This study aims to investigate structural differences in subcortical regions of aged participants with subclinical depression using 3Tesla MRI. In structural analysis, volumes of each subcortical region were measured to observe the volumetric difference and asymmetry between groups, but no significant difference was found. In addition, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) did not show any significant differences between groups. Structural analysis using probabilistic tractography indicated that the connection strength between left nucleus accumbens-right hippocampus, and right thalamus-right caudate was higher in the control group than the subclinical depression group. The differences in subcortical connection strength of subclinical depression groups, have shown to correlate with emotional and cognitive disorders, such as anxiety and memory impairment. We believe that the analysis of structural differences and cross-regional network measures in subcortical structures can help identify neurophysiological changes occurring in subclinical depression.

摘要

由于皮质下区域的结构变化，老年人群中的抑郁症已显示出神经障碍的可能性增加。然而，由于研究之间结构分析结果的不匹配以及关于亚临床抑郁症人群皮质下连接模式的研究稀缺，因此需要对与抑郁症相关的皮质下变化进行进一步调查。本研究旨在使用3特斯拉磁共振成像（MRI）调查患有亚临床抑郁症的老年参与者皮质下区域的结构差异。在结构分析中，测量每个皮质下区域的体积，以观察两组之间的体积差异和不对称性，但未发现显著差异。此外，两组之间的分数各向异性（FA）和表观扩散系数（ADC）也未显示出任何显著差异。使用概率性纤维束成像的结构分析表明，对照组中左伏隔核-右海马体以及右丘脑-右尾状核之间的连接强度高于亚临床抑郁症组。亚临床抑郁症组皮质下连接强度的差异已显示与情绪和认知障碍相关，如焦虑和记忆障碍。我们认为，对皮质下结构的结构差异和跨区域网络测量进行分析，有助于识别亚临床抑郁症中发生的神经生理变化。

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