Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
Transl Psychiatry. 2020 Feb 25;10(1):78. doi: 10.1038/s41398-020-0759-0.
Experiencing stressful events throughout one's life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6) and C-reactive protein (CRP), have been linked to both early life stress and MDD. We aimed to explore the biological stress signatures of early stress and MDD on hippocampal sub regional volumes using 7 Tesla MRI imaging. A cohort of 71 MDD patients was compared against 46 age and sex-matched healthy volunteers. MDD subjects had higher averages of IL-6 and CRP levels. These differences were significant for IL-6 levels and trended for CRP. There were no significant group differences in any of the hippocampal subfields or global hippocampal volumes; further, there were no hippocampal subfield differences between MDD subjects with high levels of our biological stress measures and MDDs with normal levels.
个体一生中经历的压力事件，尤其是儿童期创伤，会增加被诊断为重度抑郁症（MDD）的可能性。皮质醇水平升高，以及白细胞介素（IL-6）和 C 反应蛋白（CRP）等炎症标志物，与早期生活压力和 MDD 都有关。我们旨在使用 7 特斯拉 MRI 成像技术，探索早期应激和 MDD 对海马亚区体积的生物学应激特征。将 71 名 MDD 患者与 46 名年龄和性别匹配的健康志愿者进行比较。MDD 患者的平均 IL-6 和 CRP 水平较高。IL-6 水平的差异具有统计学意义，CRP 水平的差异具有趋势。在任何海马亚区或海马整体体积方面，两组之间均无显著差异；此外，在我们的生物学应激指标水平较高的 MDD 患者和正常水平的 MDD 患者之间，海马亚区也没有差异。
