Ciompi M L, Bazzichi L, Marotta G, Pasero G
Institute of Medical Pathology, University of Pisa, Italy.
Int J Tissue React. 1988;10(1):25-7.
Tigason (etretinate, RO-10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. The present study reports the results of the use of this drug in 15 patients with a confirmed diagnosis of psoriatic arthritis, aged between 42 and 74 (average 60.2) years. Two patients dropped out after one month because they showed dryness of lips, chapping and intolerable itching, and another two due to intolerable pruritus and deterioration of their skin lesions. The 11 remaining patients, five males and six females, were treated with a daily dose of 50 mg etretinate, reduced to 25 mg after two weeks. Assessments which included grip strength, Ritchie joint index, pain, and dermatological assessment were performed at monthly intervals. Routine blood tests for toxic effects and erythrocyte sedimentation rate (ESR) were also performed, as well as CPR (C-protein reactive) as a test of disease activity. All patients showed an improvement in the psoriasis, joint swelling and pain. The elevated ESR observed in all patients studied also fell gradually during the course of etretinate treatment, as did as the intake of antiinflammatory agents. Elevated serum lipid levels (cholesterol and triglycerides) were found in three patients; further drug-specific side-effects such as dryness of lips and mouth, loss of hair, thinning of skin and scaling were frequently found in all patients, but they remained tolerable.
银屑灵（依曲替酯，RO - 10 - 9359）是一种口服芳香维甲酸，对银屑病和其他皮肤病综合征有效。本研究报告了该药物用于15例确诊为银屑病关节炎患者的结果，这些患者年龄在42岁至74岁之间（平均60.2岁）。两名患者在一个月后退出，因为他们出现嘴唇干燥、皲裂和难以忍受的瘙痒，另外两名患者因难以忍受的瘙痒和皮肤病变恶化而退出。其余11名患者，5名男性和6名女性，接受每日50毫克依曲替酯的治疗，两周后减至25毫克。每月进行一次评估，包括握力、里奇关节指数、疼痛和皮肤病学评估。还进行了常规血液检查以检测毒性作用和红细胞沉降率（ESR），以及C反应蛋白（CPR）作为疾病活动度的检测。所有患者的银屑病、关节肿胀和疼痛均有改善。在所有研究患者中观察到的升高的ESR在依曲替酯治疗过程中也逐渐下降，抗炎药的摄入量也如此。三名患者出现血清脂质水平（胆固醇和甘油三酯）升高；所有患者中经常出现嘴唇和口腔干燥、脱发、皮肤变薄和脱屑等进一步的药物特异性副作用，但仍可耐受。
