Rosenthal M
Schweiz Med Wochenschr. 1979 Dec 15;109(48):1912-4.
Four patients with active seronegative psoriatic arthropathy were treated with retinoid (Ro 10-9359) in a daily dose of 30 mg for at least four months. Within the first 4--6 weeks of treatment all patients showed marked improvement of arthritis as measured by the number of swollen joints, the Ritchie joint index, morning stiffness and the pain experienced. One patient stopped taking her concomitant medication of nonsteroidal anti-inflammatory agent, while the others were able to reduce the intake of such drugs substantially. None of the patients were taking steroids. The elevated erythrocyte sedimentation rate observed in all patients studied also fell gradually in the course of treatment. With the exception of dry lips observed in two patients, other adverse effect such as extensive mucosa dryness and cheilitis, as commonly seen in patients receiving this agent, were not recorded. In view of these encouraging preliminary results we are now conducting a multicenter control study to substantiate these findings.
4例活动性血清阴性银屑病关节炎患者接受维甲酸（Ro 10-9359）治疗，每日剂量30mg，至少治疗4个月。在治疗的前4至6周内，通过肿胀关节数量、里奇关节指数、晨僵和疼痛程度衡量，所有患者的关节炎均有显著改善。1例患者停止服用其同时服用的非甾体抗炎药，其他患者能够大幅减少此类药物的摄入量。所有患者均未服用类固醇。在所有研究患者中观察到的红细胞沉降率升高在治疗过程中也逐渐下降。除2例患者出现嘴唇干燥外，未记录到接受该药物治疗的患者常见的其他不良反应，如广泛的黏膜干燥和唇炎。鉴于这些令人鼓舞的初步结果，我们目前正在进行一项多中心对照研究以证实这些发现。
