Department of Pharmacy and Center for Integrated Protein Science, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, München 81377, Germany.
Chem Commun (Camb). 2021 Jun 8;57(46):5662-5665. doi: 10.1039/d1cc01452h.
A novel chiral aromatic δ-amino acid building block was shown to fully induce handedness in quinoline oligoamide foldamers with the possibility of further increasing the bias by combining multiples of these units in the same sequence. Through its incorporation within the helix, both N- and C-termini are still accessible for further functionalisation.
一种新型手性芳香 δ-氨基酸砌块被证明能完全诱导喹啉寡酰胺类折叠物的手性，通过在同一序列中组合多个此类砌块，有可能进一步增加其手性偏向。通过将其引入螺旋结构中，N-端和 C-端仍然可以进一步进行官能化。
