Wnt/β-连环蛋白调节剂的结构修饰及大麻素类似物 cannabielsoin 结构和构型的确认。
Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration.
机构信息
Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28409, USA.
Department of Chemistry, Seton Hall University, South Orange, New Jersey 07079, USA.
出版信息
Chem Commun (Camb). 2021 Jun 8;57(46):5658-5661. doi: 10.1039/d1cc01971f.
PMID:33972980
Abstract
In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin.
摘要
在本报告中，我们修正了之前报道的合成产物的结构，该产物被提议为 1R,2S-大麻二酚环氧化物，并使用各向异性 NMR 和合成化学方法将其重新分配为大麻素。这些结果提供了大麻素与第一个已知的生物靶标和功能之间的直接联系。
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