School of Science, College of Sciences, Engineering, Computing Technologies and Health and Medical Sciences, RMIT University, Bundoora, Melbourne, VIC 3083, Australia.
NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.
Molecules. 2022 Jan 18;27(3):604. doi: 10.3390/molecules27030604.
is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of research. The evaluation of the current extraction methods implemented in the industry and scientific literature to produce consistent, reliable, and potent medicinal extracts is prudent. Furthermore, these processes must be subjected to higher levels of scientific stringency, as has been increasingly used for various ailments, and the industry is receiving acceptance in different countries. We comprehensively analysed the current literature and drew a critical summary of the extraction methods implemented thus far to recover bioactive compounds from medicinal . Moreover, this review outlines the major bioactive compounds in , discusses critical factors affecting extraction yields, and proposes future considerations for the effective extraction of bioactive compounds from . Overall, research on medicinal marijuana is limited, with most reports on the industrial hemp variety of or pure isolates. We also propose the development of sustainable extraction methods through the implementation of mathematical prediction models in future studies.
因其众多的治疗活性而闻名，这在主要基于其生物活性化合物的临床前和临床研究中得到了证实。工业正在迅速发展；因此，产品开发和提取方法已成为研究的关键方面。评估当前在工业和科学文献中实施的提取方法，以生产一致、可靠和有效的药用大麻提取物是谨慎的。此外，由于大麻被越来越多地用于各种疾病，而且该行业在不同国家得到了认可，因此这些过程必须接受更高水平的科学严格性。我们全面分析了当前的文献，并对迄今为止实施的提取方法进行了批判性总结，以从药用大麻中回收生物活性化合物。此外，本综述概述了大麻中的主要生物活性化合物，讨论了影响提取产率的关键因素，并为从大麻中有效提取生物活性化合物提出了未来的考虑因素。总体而言，药用大麻的研究有限，大多数报告都是关于工业大麻品种或纯分离物。我们还建议通过在未来的研究中实施数学预测模型来开发可持续的大麻提取方法。
