铱配合物作为一种 AIE 活性光动力治疗的光敏剂用于影像引导的光动力治疗。
An Iridium Complex as an AIE-active Photosensitizer for Image-guided Photodynamic Therapy.
机构信息
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China.
College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, P. R. China.
出版信息
Chem Asian J. 2021 Jul 5;16(13):1780-1785. doi: 10.1002/asia.202100291. Epub 2021 May 26.
Image-guided photodynamic therapy (PDT) has received growing attention due to its non-invasiveness and precise controllability. However, the PDT efficiency of most photosensitizers are decreased in living system due to the aggregation-caused singlet oxygen ( O ) generation decreasing. Herein, we present an Iridium (III) pyridylpyrrole complex (Ir-1) featuring of aggregation-induced emission (AIE) and O generation characteristics for image-guided PDT of cancer. Ir-1 aqueous solution exhibits bright red phosphorescence peaked at 630 nm, large Stokes shift of 227 nm, and good O generation ability. The O generating rate of Ir-1 in EtOH/water mixture solution is 2.3 times higher than that of Rose Bengal. In vitro experimental results revealed that Ir-1 has better biocompatibility and higher phototoxicity compared with clinically used photosensitizers (Rose Bengal and Ce6), suggesting that Ir-1 can serve as a photosensitizer for image-guided PDT of cancer.
由于其非侵入性和精确可控性，基于图像的光动力疗法（PDT）受到了越来越多的关注。然而，由于聚集引起的单线态氧（O）生成减少，大多数光敏剂的 PDT 效率在活体系统中降低。在此，我们提出了一种具有聚集诱导发射（AIE）和 O生成特性的铱（III）吡啶基吡咯配合物（Ir-1），用于癌症的基于图像的 PDT。Ir-1 水溶液在 630nm 处呈现明亮的红色磷光，Stokes 位移为 227nm，具有良好的 O 生成能力。Ir-1 在 EtOH/水溶液混合物中的 O 生成速率比 Rose Bengal 高 2.3 倍。体外实验结果表明，与临床使用的光敏剂（Rose Bengal 和 Ce6）相比，Ir-1 具有更好的生物相容性和更高的光毒性，表明 Ir-1 可以用作癌症基于图像的 PDT 的光敏剂。
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