AIE-活性铱(III)配合物与上转换纳米粒子集成，用于近红外光辐照光动力治疗。

AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy.

机构信息

Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China.

State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province 130033, China.

出版信息

Chem Commun (Camb). 2022 Sep 8;58(72):10056-10059. doi: 10.1039/d2cc03622c.

DOI:10.1039/d2cc03622c

PMID:35993197

Abstract

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high O generation ability, thereby effectively killing 4T1 mouse cancer cells . This work has potential for future photodynamic therapy (PDT) applications.

摘要

将聚集诱导发光（AIE）活性的 Ir(III) 配合物与上转换纳米粒子（UCNPs）集成，得到了近红外辐射敏化剂（PS）UCNPs@Ir-2-N。该 PS 具有良好的生物相容性、优异的光毒性、良好的细胞积累能力和高 O2 生成能力，从而有效地杀死了 4T1 小鼠癌细胞。这项工作为未来的光动力治疗（PDT）应用提供了潜力。