Kuramoto Y, Shindo Y, Tagami H
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
J Cutan Pathol. 1988 Jun;15(3):188-90. doi: 10.1111/j.1600-0560.1988.tb00541.x.
We report a 24-year-old male patient with sarcoidosis who developed subcutaneous nodules on his thighs and buttocks at the sites of repeated intramuscular injections. Histologically, there were extensive areas of caseation necrosis surrounded by typical sarcoidal granuloma. The nodules regressed spontaneously over a period of 4 months, concurrently, both his bilateral hilar adenopathy and the results of immunological tests, returned to normal. We think that these lesions developed at the sites of subcutaneous scar tissue induced by frequent injections in childhood. We believe the pathomechanism to be similar to that for scar sarcoidosis, and that the extensive caseation necrosis reflected a regressing stage of the disease.
我们报告一名24岁的结节病男性患者，其在大腿和臀部反复肌肉注射部位出现皮下结节。组织学检查显示，有广泛的干酪样坏死区域，周围是典型的结节病肉芽肿。这些结节在4个月内自行消退，同时，他双侧肺门淋巴结肿大及免疫检测结果均恢复正常。我们认为这些病变是在儿童期频繁注射引起的皮下瘢痕组织部位发展而来。我们认为其发病机制与瘢痕结节病相似，广泛的干酪样坏死反映了疾病的消退阶段。
