Department of Human Genetics, McGill University, Montréal, Québec, Canada.
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
Mov Disord. 2021 Aug;36(8):1967-1972. doi: 10.1002/mds.28640. Epub 2021 May 11.
Epidemiological studies have reported an association between Parkinson's disease (PD) and restless legs syndrome.
We aimed to use genetic data to study whether these 2 disorders are causally linked or share genetic architecture.
We performed two-sample Mendelian randomization and linkage disequilibrium score regression using summary statistics from recent genome-wide meta-analyses of PD and restless legs syndrome.
We found no evidence for a causal relationship between restless legs syndrome (as the exposure) and PD (as the outcome, inverse variance-weighted; b = -0.003, SE = 0.031, P = 0.916; F statistic = 217.5). Reverse Mendelian randomization also did not demonstrate any causal effect of PD on restless legs syndrome (inverse variance-weighted; b = -0.012, SE = 0.023, P = 0.592; F statistic = 191.7). Linkage disequilibrium score regression analysis demonstrated lack of genetic correlation between restless legs syndrome and PD (rg = -0.028, SE = 0.042, P = 0.507).
There was no evidence for a causal relationship or genetic correlation between restless legs syndrome and PD. The associations observed in epidemiological studies could be attributed, in part, to confounding or nongenetic determinants. © 2021 International Parkinson and Movement Disorder Society.
流行病学研究报告帕金森病（PD）与不安腿综合征之间存在关联。
我们旨在使用遗传数据研究这两种疾病是否存在因果关系或具有遗传结构。
我们使用最近 PD 和不安腿综合征全基因组荟萃分析的汇总统计数据，进行两样本 Mendelian 随机化和连锁不平衡评分回归。
我们没有发现不安腿综合征（作为暴露）与 PD（作为结果，反向方差加权；b = -0.003，SE = 0.031，P = 0.916；F 统计量 = 217.5）之间存在因果关系的证据。反向 Mendelian 随机化也没有证明 PD 对不安腿综合征有任何因果影响（反向方差加权；b = -0.012，SE = 0.023，P = 0.592；F 统计量 = 191.7）。连锁不平衡评分回归分析表明不安腿综合征和 PD 之间不存在遗传相关性（rg = -0.028，SE = 0.042，P = 0.507）。
不安腿综合征与 PD 之间没有因果关系或遗传相关性的证据。流行病学研究中观察到的关联部分归因于混杂或非遗传因素。© 2021 国际帕金森病和运动障碍协会。
