帕金森病患者的不安腿症状和睡眠周期性肢体运动。
Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.
机构信息
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Department of Neurology, George Washington University School of Medicine, Washington, DC, USA.
出版信息
J Parkinsons Dis. 2022;12(4):1339-1344. doi: 10.3233/JPD-213100.
BACKGROUND
The association between restless legs syndrome (RLS) and Parkinson's disease (PD) remains controversial, with epidemiologic and descriptive evidence suggesting some potential overlap while mechanistic/genetic studies suggesting relative independence of the conditions.
OBJECTIVE
To examine a known, objectively measured endophenotype for RLS, periodic leg movements (PLMS) in sleep, in patients with PD and relate that objective finding to restless legs symptoms.
METHODS
We performed polysomnography for one (n = 8) or two (n = 67) consecutive nights in 75 PD patients and examined the association of PLMS with restless legs symptoms.
RESULTS
We found no association between restless legs symptoms and PLMS in PD. Prevalence of both was similar to data reported previously in other PD samples.
CONCLUSION
We interpret these results as suggesting that restless legs symptoms in PD patients may represent a different phenomenon and pathophysiology than RLS in the non-PD population.
背景
不宁腿综合征（RLS）与帕金森病（PD）之间的关联仍存在争议，流行病学和描述性证据表明两者存在一定程度的重叠，而机制/遗传研究则表明这两种情况相对独立。
目的
检查帕金森病患者的一种已知的、客观测量的 RLS 内表型，即睡眠中的周期性肢体运动（PLMS），并将这一客观发现与不宁腿症状联系起来。
方法
我们对 75 名 PD 患者进行了一次（n=8）或两次（n=67）连续的多导睡眠图检查，并研究了 PLMS 与不宁腿症状之间的关联。
结果
我们发现 PD 患者的不宁腿症状与 PLMS 之间没有关联。两者的患病率与先前在其他 PD 样本中报告的数据相似。
结论
我们将这些结果解释为，PD 患者的不宁腿症状可能代表与非 PD 人群中的 RLS 不同的现象和病理生理学。
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