基质内注射万古霉素以最大限度提高其对耐甲氧西林金黄色葡萄球菌角膜炎的早期效果：一项兔研究。
Intrastromal Administration of Vancomycin to Maximize Its Early Effect on Methicillin-resistant Staphylococcus Aureus Keratitis: A Rabbit Study.
机构信息
Department of Ophthalmology, Bolu Abant Izzet Baysal University, Training and Research Hospital, Bolu, Turkey.
Department of Medical Microbiology, Bolu Abant Izzet Baysal University, Training and Research Hospital, Bolu, Turkey.
出版信息
Ocul Immunol Inflamm. 2022 Aug;30(6):1430-1435. doi: 10.1080/09273948.2021.1887280. Epub 2021 May 11.
PURPOSE
To evaluate the early efficacy of intrastromal injection of vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA).
METHODS
Twenty-four eyes of 24 New-Zealand White rabbits were included in the study. MRSA keratitis was induced in the right eye of each rabbit. On the 24 hour after the inoculation of MRSA, eight rabbits received topical vancomycin therapy, eight rabbits received intrastromal vancomycin therapy, and eight rabbits received balanced salt solution and served as the control group.
RESULTS
The pre-post differences in epithelial erosion score and total clinical score were higher in the topical vancomycin group than in the intrastromal vancomycin group ( = .033 and 0.016, respectively). The eyes treated topically had higher bacterial load compared with those treated intrastromally (6.97 ± 0.82 vs. 6.14 ± 0.63 log10 CFU/g, = .039).
CONCLUSION
A single dose of intrastromal vancomycin is more effective than the standard loading dose of topical vancomycin in reducing bacterial load.
目的
评估基质内注射万古霉素治疗耐甲氧西林金黄色葡萄球菌（MRSA）的早期疗效。
方法
本研究纳入 24 只新西兰白兔的 24 只眼。每只兔子的右眼均诱导 MRSA 角膜炎。在接种 MRSA 后 24 小时，8 只兔子接受局部万古霉素治疗，8 只兔子接受基质内万古霉素治疗，8 只兔子接受平衡盐溶液作为对照组。
结果
与基质内万古霉素组相比，局部万古霉素组的上皮侵蚀评分和总临床评分的前后差值更高（分别为 0.033 和 0.016）。局部治疗的眼细菌载量高于基质内治疗的眼（6.97 ± 0.82 对 6.14 ± 0.63 log10 CFU/g， = 0.039）。
结论
单次基质内万古霉素注射比标准负荷剂量局部万古霉素更有效地降低细菌载量。
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