Howes E L, Kwok M T, McKay D G
Am J Pathol. 1978 Jan;90(1):7-22.
The antiflammatory drug indomethacin, an inhibitor of prostaglandin synthesis, prevents the generalized Shwartzman reaction produced in rabbits by two intravenous injections of bacterial endotoxin. Indomethacin has this effect if given before the first but not the second injection of endotoxin. Measurements of circulating white blood cells, platelets, partial thromboplastin time, prothrombin time, fibrinogen, plasminogen, and soluble fibrin were made at several times after either the first or second injection of endotoxin treated and nontreated rabbits. Four hours after the first injection of endotoxin, leukopenia and thrombocytopenia were somewhat greater in treated rabbits and the prolongation of the activated partial thromboplastin time was shortened. Twenty-one hours after injection of endotoxin, leukocytosis and elevation of plasma fibrinogen were not as great in treated animals. Four hours following the second injection of endotoxin a decrease in fibrinogen, prolongation of the prothrombin time, and the elaboration of soluble fibrin were consistently found in rabbits with the generalized Shwartzman reaction. In treated rabbits, none of these changes occurred. Indomethacin prevents the generalized Shwartzman reaction by preventing the development of the prepared state in this endotoxin model.
抗炎药物吲哚美辛是一种前列腺素合成抑制剂，可预防家兔因两次静脉注射细菌内毒素而产生的全身性施瓦茨曼反应。如果在第一次但不是第二次注射内毒素之前给予吲哚美辛，它就会产生这种效果。在第一次或第二次注射内毒素后，对经处理和未处理的家兔在几个时间点测量循环白细胞、血小板、部分凝血活酶时间、凝血酶原时间、纤维蛋白原、纤溶酶原和可溶性纤维蛋白。第一次注射内毒素后4小时，经处理的家兔白细胞减少和血小板减少更为明显，活化部分凝血活酶时间的延长缩短。注射内毒素21小时后，经处理的动物白细胞增多和血浆纤维蛋白原升高的程度较小。第二次注射内毒素4小时后，全身性施瓦茨曼反应的家兔中始终发现纤维蛋白原减少、凝血酶原时间延长和可溶性纤维蛋白形成。在经处理的家兔中，这些变化均未发生。吲哚美辛通过阻止该内毒素模型中预致敏状态的发展来预防全身性施瓦茨曼反应。
