Department of Emergency, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and School of Chemical Engineering, Sichuan University, Chengdu, 610041, China.
Org Lett. 2021 May 21;23(10):3818-3822. doi: 10.1021/acs.orglett.1c00835. Epub 2021 May 11.
Here we report a general and mild approach to prepare α-branched aliphatic amines from imines. This method capitalizes on a cobalt-catalyzed umpolung alkylation of imines, employs easily available reaction partners, and demonstrates a broad substrate scope. Mechanistic studies suggest this transformation occurs by a radical pathway.
在这里，我们报道了一种从亚胺制备α-支链脂肪胺的通用且温和的方法。该方法利用钴催化的亚胺反转烷基化反应，采用易得的反应试剂，并展示了广泛的底物范围。机理研究表明，这种转化是通过自由基途径进行的。
