Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Cancer Cell. 2021 May 10;39(5):596-598. doi: 10.1016/j.ccell.2021.03.011.
Su et al. demonstrate that upon inhibiting autophagy, an intracellular nutrient recycling pathway, pancreatic ductal adenocarcinoma cells upregulate NRF2-mediated transcription of macropinocytosis pathway components, thereby triggering an alternate route for tumors to scavenge nutrients from extracellular sources. Accordingly, the combined inhibition of autophagy and macropinocytosis may improve cancer treatment.
苏等人证明，在抑制自噬（一种细胞内营养回收途径）后，胰腺导管腺癌细胞上调 NRF2 介导的巨胞饮途径成分的转录，从而触发肿瘤从细胞外来源摄取营养的替代途径。因此，联合抑制自噬和巨胞饮可能会改善癌症治疗。
