Joyce P R
Department of Psychological Medicine, Christchurch School of Medicine, Sunnyside Hospital, New Zealand.
Int Clin Psychopharmacol. 1988 Apr;3(2):123-9. doi: 10.1097/00004850-198804000-00003.
Eighteen patients with rapid cycling bipolar affective disorder were recruited for an open trial of carbamazepine. Of these patients all but 2 had been resistant to lithium prophylaxis. Twelve of the patients were able to complete at least 6 months on carbamazepine. Of these 12 patients, 2 had a complete remission of their affective disorders on carbamazepine alone, 2 completely responded to combined lithium and carbamazepine treatment, 3 had a slight beneficial effect from the drug, and for the other 5 patients carbamazepine was of no therapeutic benefit. This suggests that, while carbamazepine is effective for some rapid cycling patients, for the majority alternative treatment strategies are still required.
招募了18名快速循环型双相情感障碍患者参加卡马西平的开放试验。这些患者中除2人外，其余均对锂盐预防治疗耐药。12名患者能够接受至少6个月的卡马西平治疗。在这12名患者中，2名仅使用卡马西平就使情感障碍完全缓解，2名对锂盐和卡马西平联合治疗完全有效，3名患者从该药物中获得轻微益处，另外5名患者使用卡马西平无治疗效果。这表明，虽然卡马西平对一些快速循环型患者有效，但对大多数患者仍需要其他治疗策略。
