Laird L K, Knox E P
Department of Hospital Pharmacy Practice and Administration, Medical University of South Carolina, Charleston 29425.
Pharmacotherapy. 1987;7(4):130-2. doi: 10.1002/j.1875-9114.1987.tb04038.x.
A 34-year-old white female with a long-standing and deteriorating course of rapid cycling affective disorder was successfully treated by discontinuing a tricyclic antidepressant drug and then using a combination of carbamazepine and lithium. This suggests that rapid cycling affective disorder could be an underdiagnosed disorder, especially in patients with affective disorders who are receiving conventional antidepressant drugs who otherwise exhibit a stormy clinical course with numerous medication changes and hospitalizations. It is further suggested that a change in treatment strategy is warranted in such patients, as it could benefit both patients and society by decreasing hospitalizations and increasing the patients' quality of life.
一名34岁患有长期且病情不断恶化的快速循环型情感障碍的白人女性，通过停用一种三环类抗抑郁药物，然后联合使用卡马西平和锂盐成功得到治疗。这表明快速循环型情感障碍可能是一种诊断不足的疾病，尤其在那些正在接受传统抗抑郁药物治疗的情感障碍患者中，否则这些患者会表现出临床过程反复无常，伴有多次药物调整和住院治疗。进一步表明，对于此类患者有必要改变治疗策略，因为这可能通过减少住院次数和提高患者生活质量，使患者和社会都受益。
