Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Chem Rev. 2021 May 12;121(9):5095-5097. doi: 10.1021/acs.chemrev.1c00010.
All living cells are surrounded by lipidic membranes that separate metabolic and macromolecular biosynthetic processes from external environments. Biological membranes vary dramatically in their composition and structures and are optimized by mega-annum of evolution to effectively carry out diverse biological functions including energy production, biosynthetic reactions, signaling, uptake of nutrients and active efflux, and others. This thematic issue of , "Transporters, Porins, and Efflux Pumps", is focused on the function of biological membranes as a permeability barrier and on the proteins that create, maintain, and bypass this barrier. Effective therapeutic interventions rely on active and passive permeation of various molecules and compounds across membranes, and our successes in development of such therapeutics are strongly affected by structural and functional insights into the assembly and function of cellular permeation barriers.
所有活细胞都被脂膜所包围，这些脂膜将代谢和大分子生物合成过程与外部环境隔离开来。生物膜在组成和结构上有很大的差异，经过数亿年的进化，它们被优化以有效地执行多种生物功能，包括能量产生、生物合成反应、信号传递、营养物质摄取和主动外排等。本期《 》的主题是“转运蛋白、孔蛋白和外排泵”，重点介绍生物膜作为渗透屏障的功能，以及创造、维持和绕过这一屏障的蛋白质。有效的治疗干预依赖于各种分子和化合物在膜上的主动和被动渗透，我们在开发此类治疗方法方面的成功受到对细胞渗透屏障组装和功能的结构和功能见解的强烈影响。
