Kidogami Shinya, Endo Shunji, Tamura Shigeyuki, Murotani Masatoshi, Shigetsu Kaichi, Yoneda Naoki, Imamura Hiroki, Mokutani Yukako, Kishimoto Tomoya, Hashimoto Yasuji, Hirose Hajime, Yoshioka Shinichi, Sasaki Yoh
Dept. of Surgery, Yao Municipal Hospital.
Gan To Kagaku Ryoho. 2021 Apr;48(4):575-577.
A 74‒year‒old man was diagnosed with advanced gastric cancer with para‒aortic lymph node metastasis and ascites. He has been treated with S‒1 plus oxaliplatin as the primary treatment, paclitaxel plus ramucirumab as the secondary treatment and CPT‒11 as the third‒line treatment, but the effect of all treatments were temporary and left adrenal metastasis appeared during the course. Nivolumab was started as the fourth‒line treatment. Two months later, para‒aortic lymph nodes and left adrenal metastasis were markedly shrank and ascites disappeared. A 79 years old woman was performed proximal gastrectomy for advanced gastric cancer of the upper stomach. S‒1 therapy was started as adjuvant chemotherapy, but tumor markers have been increased and para‒aortic lymph node recurrence was observed 4 months after the operation. After ramucirumab as the primary treatment was ineffective, nivolumab was started as the secondary treatment. Two months later, para‒aortic lymph nodes shrank below the significant size and tumor markers were normalized.
一名74岁男性被诊断为晚期胃癌伴主动脉旁淋巴结转移和腹水。他接受了以S-1联合奥沙利铂作为一线治疗、紫杉醇联合雷莫西尤单抗作为二线治疗以及伊立替康作为三线治疗，但所有治疗效果均为暂时的，病程中出现了左肾上腺转移。纳武利尤单抗作为四线治疗开始使用。两个月后，主动脉旁淋巴结和左肾上腺转移明显缩小，腹水消失。一名79岁女性因胃上部的晚期胃癌接受了近端胃切除术。开始使用S-1治疗作为辅助化疗，但术后4个月肿瘤标志物升高，观察到主动脉旁淋巴结复发。在一线治疗雷莫西尤单抗无效后，纳武利尤单抗作为二线治疗开始使用。两个月后，主动脉旁淋巴结缩小至显著尺寸以下且肿瘤标志物恢复正常。
