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非甾体抗炎药:结肠肿物的罕见病因

Non-Steroidal Anti-Inflammatory Drugs: A Rare Cause of Colonic Mass.

作者信息

Baiomi Ahmed, Abbas Hafsa, Mehershahi Shehriyar, Daniel Myrta

机构信息

Department of Medicine, BronxCare Health System, Bronx, New York, USA.

Division of Gastroenterology, BronxCare Health System, Bronx, New York, USA.

出版信息

Case Rep Gastroenterol. 2021 Mar 18;15(1):395-399. doi: 10.1159/000511748. eCollection 2021 Jan-Apr.

DOI:10.1159/000511748
PMID:33976617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8077422/
Abstract

NSAIDs (non-steroidal anti-inflammatory drugs) are one of the most used medications worldwide. Every day they are used by more than 30 million Americans. Here, we report a rare and interesting case of a 63-year-old woman with a history of NSAID use who presented to our emergency room with lower abdominal pain. Computed tomography (CT) scan of the abdomen with intravenous contrast revealed focal mucosal thickening in the cecum which was highly suspicious for colonic malignancy. She had a colonoscopy which showed two masses and ulcers in the right colon, pathology was negative for malignancy and showed inflammation consistent with NSAID colopathy.

摘要

非甾体抗炎药(NSAIDs)是全球使用最广泛的药物之一。每天有超过3000万美国人使用它们。在此,我们报告一例罕见且有趣的病例,一名63岁有非甾体抗炎药使用史的女性因下腹部疼痛就诊于我们的急诊室。腹部增强计算机断层扫描(CT)显示盲肠局灶性黏膜增厚,高度怀疑为结肠恶性肿瘤。她接受了结肠镜检查,结果显示右半结肠有两个肿块和溃疡,病理检查排除恶性肿瘤,显示为与非甾体抗炎药结肠病相符的炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41b/8077422/fa307e0028d7/crg-0015-0395-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41b/8077422/7e91e936cba8/crg-0015-0395-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41b/8077422/fa307e0028d7/crg-0015-0395-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41b/8077422/7e91e936cba8/crg-0015-0395-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41b/8077422/fa307e0028d7/crg-0015-0395-g02.jpg

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引用本文的文献

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Colonic Mass After NSAID Use and Concerns for Malignancy.使用非甾体抗炎药后出现结肠肿物及对恶性肿瘤的担忧。
ACG Case Rep J. 2023 Oct 11;10(10):e01151. doi: 10.14309/crj.0000000000001151. eCollection 2023 Oct.

本文引用的文献

1
Lower Gastrointestinal Bleeding due to Non-Steroid Anti-Inflammatory Drug-Induced Colopathy Case Report and Literature Review.非甾体抗炎药所致结肠病引起的下消化道出血:病例报告及文献综述
Middle East J Dig Dis. 2013 Apr;5(2):107-11.
2
Clinical, endoscopic and pathologic spectrum of non-steroidal anti-inflammatory drug-induced colitis.非甾体抗炎药诱导的结肠炎的临床、内镜及病理表现谱
Indian J Gastroenterol. 2009 Jul-Aug;28(4):150-3. doi: 10.1007/s12664-009-0053-9. Epub 2009 Nov 24.
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Adverse effects of nonsteroidal anti-inflammatory drugs on the colon.
非甾体抗炎药对结肠的不良反应。
Curr Gastroenterol Rep. 2008 Oct;10(5):485-9. doi: 10.1007/s11894-008-0089-5.
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Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy.经双气囊内镜检查发现的非甾体抗炎药所致小肠损伤
World J Gastroenterol. 2005 Aug 21;11(31):4861-4. doi: 10.3748/wjg.v11.i31.4861.
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Visible small-intestinal mucosal injury in chronic NSAID users.慢性非甾体抗炎药使用者可见小肠黏膜损伤。
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Ulcerative ileitis encountered at ileo-colonoscopy: likely role of nonsteroidal agents.回结肠镜检查时发现的溃疡性回肠炎:非甾体类药物的可能作用
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