Takahashi Osamu, Sakakibara Ryuji, Shimizu Ayami, Tateno Fuyuki, Aiba Yosuke
Clinical Physiology Unit, Sakura Medical Center, Toho University, Sakura, Japan.
Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
Case Rep Neurol. 2021 Mar 19;13(1):200-204. doi: 10.1159/000514244. eCollection 2021 Jan-Apr.
It has not yet been clarified whether atherosclerotic risks other than diabetes are related to bladder small fiber neuropathy (cystopathy) in type 2 diabetes. The aim of this study was to answer this question by urodynamics. This was a retrospective study. The subjects were 44 patients: 27 male, 17 female; mean age 67.0 ± 12.7 years; mean duration of diabetes 16.8 ± 13.1 years; mean HbA1c 7.8 ± 1.2%. We analyzed the relationship between diabetic cystopathy (at least one of the following abnormalities in urodynamics: decreased bladder sensation, post-void residual, detrusor overactivity, low-compliance detrusor) and clinical items, i.e., severity and duration of diabetes, nerve conduction, body mass index, blood pressure, cardio-ankle vascular stiffness index, and ultrasound Doppler echography (plaque score, intima-media thickness) in these patients. As a result, urodynamic diabetic cystopathy was not correlated with any of the above systemic items. In conclusion, the above findings suggest that bladder small fiber neuropathy can occur independently from systemic atherosclerotic risks.
2型糖尿病中，除糖尿病外的动脉粥样硬化风险是否与膀胱小纤维神经病变（膀胱病）相关，目前尚未明确。本研究旨在通过尿动力学来回答这一问题。这是一项回顾性研究。研究对象为44例患者，其中男性27例，女性17例；平均年龄67.0±12.7岁；糖尿病平均病程16.8±13.1年；平均糖化血红蛋白7.8±1.2%。我们分析了糖尿病膀胱病（尿动力学中至少存在以下一种异常：膀胱感觉减退、残余尿量、逼尿肌过度活动、低顺应性逼尿肌）与这些患者的临床指标之间的关系，这些临床指标包括糖尿病的严重程度和病程、神经传导、体重指数、血压、心踝血管僵硬指数以及超声多普勒超声检查（斑块评分、内膜中层厚度）。结果显示，尿动力学糖尿病膀胱病与上述任何一项全身指标均无相关性。总之，上述研究结果表明，膀胱小纤维神经病变可能独立于全身动脉粥样硬化风险而发生。
