Clinical Physiology Unit, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura 285-8741, Japan.
Neurology, Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura 285-8741, Japan.
Auton Neurosci. 2020 Jan;223:102600. doi: 10.1016/j.autneu.2019.102600. Epub 2019 Nov 18.
Several studies have shown relationship between the lower urinary tract dysfunction (LUTD) and atherosclerosis. However, no study is available to see which LUTD relates more to atherosclerosis, among detrusor overactivity and post-void residual. In order to answer this question, we present data of urodynamic and atherosclerosis tests.
We performed standard urodynamics and two atherosclerosis tests, i.e., a cardio-ankle vascular stiffness index (CAVI) test and a duplex carotid ultrasonography.
We have 183 patients; 109 men (mean age 66.3 years), 74 women (mean age 66.4 years); all age > 60 years.
Detrusor overactivity is related with high CAVI value (p < 0.05) but not with carotid intima-media thickness. Post-void residuals did not show such relation.
Urodynamic LUTD, particularly detrusor overactivity that may indicate central etiology is positively related with systemic atherosclerosis as measured by CAVI. Post-void residuals that may indicate peripheral etiology did not show such relation.
多项研究表明下尿路功能障碍（LUTD）与动脉粥样硬化之间存在关联。然而，目前尚无研究可确定逼尿肌过度活动和残余尿量与动脉粥样硬化的相关性更高。为了回答这个问题，我们提供了尿动力学和动脉粥样硬化测试的数据。
我们进行了标准的尿动力学和两种动脉粥样硬化测试，即心血管踝血管僵硬指数（CAVI）测试和颈动脉双功能超声检查。
我们纳入了 183 名患者，109 名男性（平均年龄 66.3 岁），74 名女性（平均年龄 66.4 岁），年龄均>60 岁。
逼尿肌过度活动与高 CAVI 值相关（p<0.05），但与颈动脉内膜中层厚度无关。残余尿量则未显示出这种相关性。
尿动力学下尿路功能障碍，特别是可能提示中枢病因的逼尿肌过度活动，与 CAVI 测量的系统性动脉粥样硬化呈正相关。可能提示外周病因的残余尿量则未显示出这种相关性。
