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微小RNA-202-5p通过抑制PTEN促进结直肠癌发生。

MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN.

作者信息

Huang Jing, Zhang Yaqin, Xu Yuan, Xie Qi, Wu Shuang, Dong Yi, Chen Bing, Xia Yang, Guo Lili, Li Qun, Gu Hao, Hu Wanglai

机构信息

Department of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.

Translational Research Institute, Henan Provincial People's Hospital, Molecular Pathology Center, Academy of Medical Science, Zhengzhou University, Zhengzhou, China, 450003.

出版信息

J Cancer. 2021 Mar 31;12(11):3154-3163. doi: 10.7150/jca.56186. eCollection 2021.

DOI:10.7150/jca.56186
PMID:33976725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8100819/
Abstract

Colorectal cancer (CRC) is still one of the leading causes of cancer-associated death in the modern society. The biological function of miR-202-5p for CRC development remains controversial, largely due to the fact that miR-202-5p can be tumor-suppressive or oncogenic in different contexts. Obtained results indicated that aberrant expression of miR-202-5p was observed in majority of human CRC samples and miR-202-5p was transcriptionally up-regulated by c-Myc. In addition, miR-202-5p functions to promote the activation of PI3K/Akt signaling pathway by directly suppressing PTEN. Silencing or enforced expression of miR-202-5p resulted in CRC cell proliferation inhibition and enhancement, respectively. Importantly, decreased PTEN level and increased phosphorylation of Akt were frequently associated with elevated miR-202-5p expression in colorectal cancer tissues. Increased miR-202-5p expression may serve as a tumor promoter by directly targeting PTEN in colorectal cancer.

摘要

在现代社会中，结直肠癌（CRC）仍是癌症相关死亡的主要原因之一。miR-202-5p在结直肠癌发生发展中的生物学功能仍存在争议，这主要是因为miR-202-5p在不同情况下可能具有肿瘤抑制或致癌作用。所得结果表明，在大多数人类结直肠癌样本中观察到miR-202-5p表达异常，且miR-202-5p受c-Myc转录上调。此外，miR-202-5p通过直接抑制PTEN来促进PI3K/Akt信号通路的激活。沉默或过表达miR-202-5p分别导致结直肠癌细胞增殖受到抑制和增强。重要的是，在结直肠癌组织中，PTEN水平降低和Akt磷酸化增加常与miR-202-5p表达升高相关。在结直肠癌中，miR-202-5p表达增加可能通过直接靶向PTEN而起到肿瘤促进作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/18bb5de5cc3d/jcav12p3154g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/d145fb391f08/jcav12p3154g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/f081c66718c0/jcav12p3154g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/6f3e22343135/jcav12p3154g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/dd0427e1eda2/jcav12p3154g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/18bb5de5cc3d/jcav12p3154g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/d145fb391f08/jcav12p3154g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/f081c66718c0/jcav12p3154g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/6f3e22343135/jcav12p3154g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/dd0427e1eda2/jcav12p3154g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4d/8100819/18bb5de5cc3d/jcav12p3154g005.jpg

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Cancer Commun (Lond). 2020 Sep;40(9):456-460. doi: 10.1002/cac2.12079. Epub 2020 Jul 22.
2
Colorectal cancer statistics, 2020.2020 年结直肠癌统计数据。
CA Cancer J Clin. 2020 May;70(3):145-164. doi: 10.3322/caac.21601. Epub 2020 Mar 5.
3
Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2.类固醇生成因子 1（SF1）对 miR-202-5p 的转录激活通过靶向 TGFβR2 诱导山羊颗粒细胞凋亡。
Cells. 2020 Feb 14;9(2):445. doi: 10.3390/cells9020445.
4
Time from diagnosis to treatment of colorectal cancer in a South Australian clinical registry cohort: how it varies and relates to survival.在南澳大利亚临床注册队列中，结直肠癌的诊断到治疗时间：它如何变化以及与生存的关系。
BMJ Open. 2019 Sep 30;9(9):e031421. doi: 10.1136/bmjopen-2019-031421.
5
MiR-202 inhibits the proliferation and invasion of colorectal cancer by targeting UHRF1.微小RNA-202通过靶向UHRF1抑制结直肠癌的增殖和侵袭。
Acta Biochim Biophys Sin (Shanghai). 2019 Dec 13;51(12):1305-1306. doi: 10.1093/abbs/gmz088.
6
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Cancer Biol Ther. 2019;20(7):989-998. doi: 10.1080/15384047.2019.1591674. Epub 2019 Apr 14.
7
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8
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Gene. 2018 Nov 15;676:329-335. doi: 10.1016/j.gene.2018.08.064. Epub 2018 Aug 23.
9
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Oncol Lett. 2018 Jul;16(1):829-834. doi: 10.3892/ol.2018.8694. Epub 2018 May 10.
10
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