Yepuri Natesh, Vanga Gautam R, Naous Rana, Pasham Sudhir, Ponnekanti Sravan, Kinthala Sudhakar
Department of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Department of Anesthesiology, Robert Packer Hospital, Sayre, PA, USA.
J Surg Case Rep. 2021 May 4;2021(5):rjab159. doi: 10.1093/jscr/rjab159. eCollection 2021 May.
Gangliocytic paragangliomas (GP) are rare tumors encountered exclusively in the second portion of the duodenum. Duodenal gangliocytic paraganglioma (DGP) belongs to a subclass of neuroendocrine neoplasms, characterized with unique histologic features of carcinoid tumor, paraganglioma and ganglioneuromas. According to the recent World Health Organization classification of gastrointestinal neuroendocrine tumors (NETs), there is a debate to classify them either as low-grade NETs or as an independent entity. There are a few reports of regional lymph node (LN) metastasis that could argue DGP as a true neoplasm. However, majority of them had a benign course, raising the question of whether long-term follow-up is required. We report a case of a retroperitoneal LN involvement by metastatic GP and additionally performed a systematic review of the literature to determine the optimal follow-up, since no guidelines exist for this rare entity.
神经节细胞性副神经节瘤（GP）是一种罕见肿瘤，仅见于十二指肠第二部。十二指肠神经节细胞性副神经节瘤（DGP）属于神经内分泌肿瘤的一个亚类，其特征为具有类癌、副神经节瘤和神经节神经瘤独特的组织学特征。根据世界卫生组织最近对胃肠道神经内分泌肿瘤（NETs）的分类，对于将它们归类为低级别NETs还是作为一个独立实体存在争议。有一些关于区域淋巴结（LN）转移的报道，这可能支持将DGP视为一种真正的肿瘤。然而，它们中的大多数病程呈良性，这就引发了是否需要长期随访的问题。我们报告一例转移性GP累及腹膜后LN的病例，并另外对文献进行了系统综述以确定最佳随访方案，因为目前尚无针对这种罕见实体的指南。
