Park Hyung Kyu, Han Hye Seung
From the Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Arch Pathol Lab Med. 2016 Jan;140(1):94-8. doi: 10.5858/arpa.2014-0456-RS.
Gangliocytic paraganglioma is a rare tumor that occurs most commonly in the second portion of the duodenum. It is characterized by its triphasic cellular differentiation: epithelioid neuroendocrine cells, spindle cells with Schwann cell differentiation, and ganglion cells. Most gangliocytic paragangliomas are considered benign and are amenable to local excision. However, to our knowledge, 23 cases with lymph node metastasis have been reported, 1 case of bone metastasis, and 2 cases of liver metastases. Predictive factors that have been suggested for lymph node metastasis include size (larger than 2 cm), young age, and tumors exceeding the submucosal layer. Our objective was to review the clinical features, the histopathologic characteristics, and the differential diagnosis of gangliocytic paraganglioma and to discuss the value of the predictive factors for lymph node metastasis.
神经节细胞性副神经节瘤是一种罕见肿瘤，最常发生于十二指肠第二段。其特征为具有三相细胞分化：上皮样神经内分泌细胞、具有施万细胞分化的梭形细胞和神经节细胞。大多数神经节细胞性副神经节瘤被认为是良性的，可进行局部切除。然而，据我们所知，已有23例淋巴结转移、1例骨转移和2例肝转移的病例报道。已提出的淋巴结转移预测因素包括大小（大于2 cm）、年轻以及肿瘤超出黏膜下层。我们的目的是回顾神经节细胞性副神经节瘤的临床特征、组织病理学特征和鉴别诊断，并讨论淋巴结转移预测因素的价值。
