无症状脑震荡患者皮质血流动力学反应的持续改变。
Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients.
作者信息
Memmini Allyssa K, Sun Xin, Hu Xiaosu, Kim Jessica, Herzog Noelle K, Islam Mohammed N, Weissman Daniel H, Rogers Alexander J, Kovelman Ioulia, Broglio Steven P
机构信息
Michigan Concussion Center, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Concussion. 2020 Oct 28;6(1):CNC84. doi: 10.2217/cnc-2020-0014.
AIM
The underlying neurophysiological effects of concussion often result in attenuated cognitive and cortical function. To understand the relation between cognition and brain injury, we investigated the effects of concussion on attentional networks using functional near-infrared spectroscopy (fNIRS).
MATERIALS & METHODS: Healthy controls and concussed patients, tested within 72 h from injury (T1) and after symptoms resolved (T2) completed a computerized attention task during fNIRS imaging.
RESULTS
T1 patients exhibited slower reaction times and reduced brain activation pattern relative to healthy controls. Interestingly, the cortical oxygenation hemoglobin response at T2 was greater relative to T1 and healthy controls, while reaction time was normative.
CONCLUSION
The exploratory findings of this study suggest once asymptomatic, a compensatory hemodynamic response may support the restoration of reaction time despite ongoing physiological recovery.
目的
脑震荡潜在的神经生理效应常常导致认知和皮质功能减弱。为了解认知与脑损伤之间的关系，我们使用功能近红外光谱技术（fNIRS）研究了脑震荡对注意力网络的影响。
材料与方法
健康对照组和脑震荡患者在受伤后72小时内（T1）以及症状缓解后（T2）进行测试，在fNIRS成像期间完成一项计算机化注意力任务。
结果
与健康对照组相比，T1期患者的反应时间较慢，脑激活模式减少。有趣的是，T2期的皮质氧合血红蛋白反应相对于T1期和健康对照组更大，而反应时间则正常。
结论
本研究的探索性结果表明，一旦无症状，尽管生理恢复仍在进行，但代偿性血流动力学反应可能支持反应时间的恢复。
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