Ponce Health Sciences University, Ponce, PR, USA.
Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA.
Pediatr Dermatol. 2021 Jul;38(4):904-907. doi: 10.1111/pde.14627. Epub 2021 May 11.
Mucous membrane pemphigoid (MMP) is a rare chronic immunobullous disease that involves the mucous membranes and may result in significant scarring and complications if diagnosis is delayed. MMP typically occurs in elderly patients, with very few cases reported in children. Here, we present a 12-year-old female patient with childhood-onset oral and genital MMP, clinically suspected to be lichen sclerosus, but eventually diagnosed as MMP after multiple supportive biopsies and confirmatory direct immunofluorescence. Although treatment was challenging, the combined use of systemic corticosteroids, dapsone, and mycophenolate mofetil was ultimately successful in achieving disease control.
黏膜类天疱疮（Mucous membrane pemphigoid，MMP）是一种罕见的慢性免疫性大疱病，累及黏膜，如果诊断延迟，可能导致严重的瘢痕和并发症。MMP 通常发生在老年患者中，儿童病例非常少见。在这里，我们报告了一例 12 岁女性儿童期口腔和生殖器 MMP 患者，临床疑似硬皮病样扁平苔藓，但最终通过多次支持性活检和确认性直接免疫荧光检查诊断为 MMP。尽管治疗具有挑战性，但联合使用全身皮质类固醇、氨苯砜和霉酚酸酯最终成功地控制了疾病。
