Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Jordan University of Science and Technology
Department of Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Hokkaido, Japan
Eur J Dermatol. 2022 May 1;32(3):312-321. doi: 10.1684/ejd.2021.4132.
Mucous membrane pemphigoid (MMP) is a rare group of heterogeneous chronic autoimmune diseases that predominantly manifest as blistering of the mucous membranes. MMP lesions often heal with scarring, which may result in impaired organ function and significant morbidity. The exact pathogenic mechanisms of MMP are still largely unknown while the diagnosis is based on a combination of clinical, histological and immuno-pathological findings. Several treatment modalities of MMP are available and are reported in the literature, however, such treatment options are principally guided by expert opinions and descriptive reports. Non-specific immunosuppression, especially corticosteroids, remains the mainstay of treatment, which often leads to severe adverse effects. Therefore, safer and more effective therapeutic modalities are required. This comprehensive literature review outlines the current knowledge and recent advances in the field of MMP management, with particular emphasis on the oral variant of MMP.
黏膜类天疱疮（Mucous membrane pemphigoid，MMP）是一组罕见的异质性慢性自身免疫性疾病，主要表现为黏膜水疱。MMP 病变常伴有瘢痕形成，导致器官功能受损和严重的发病率。虽然 MMP 的确切发病机制仍知之甚少，但诊断是基于临床、组织学和免疫病理学发现的综合判断。有多种 MMP 的治疗方法，并在文献中有报道，但这些治疗选择主要是根据专家意见和描述性报告。非特异性免疫抑制，特别是皮质类固醇，仍然是治疗的主要手段，但往往会导致严重的不良反应。因此，需要更安全、更有效的治疗方法。本综述全面概述了 MMP 管理领域的现有知识和最新进展，特别强调了 MMP 的口腔变异型。
