Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
ECA Healthcare Inc., Shanghai 201101, China.
Food Funct. 2021 May 11;12(9):4021-4033. doi: 10.1039/d0fo03471a.
Docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) has attracted increasing attention because of its unique health benefits. In this study, DHA-PS was biosynthesized from DHA-enriched phosphatidylcholine (DHA-PC), which was extracted from herring roe, Clupea harengus. The ameliorating effect of DHA-PS on high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) was investigated using a mouse model. The DHA-PS treatment ameliorated NAFLD and effectively decreased the serum total cholesterol, triglyceride, non-esterified fatty acid, and low-density lipoprotein cholesterol levels and considerably increased the serum high-density lipoprotein cholesterol levels. Moreover, the DHA-PS treatment reduced the levels of liver-function enzymes and pro-inflammatory cytokines and also the oxidative stress indices. Furthermore, DHA-PS increased the diversity and richness of the beneficial intestinal microorganisms, suggesting its potential as a dietary supplement and functional food to combat HFD-induced NAFLD.
二十二碳六烯酸（DHA）富集磷脂酰丝氨酸（DHA-PS）因其独特的健康益处而受到越来越多的关注。在本研究中，从鲱鱼卵（Clupea harengus）中提取的富含二十二碳六烯酸的磷脂酰胆碱（DHA-PC）生物合成了 DHA-PS。使用小鼠模型研究了 DHA-PS 对高脂肪饮食（HFD）诱导的非酒精性脂肪性肝病（NAFLD）的改善作用。DHA-PS 治疗改善了 NAFLD，并有效降低了血清总胆固醇、甘油三酯、非酯化脂肪酸和低密度脂蛋白胆固醇水平，显著提高了血清高密度脂蛋白胆固醇水平。此外，DHA-PS 降低了肝功能酶和促炎细胞因子以及氧化应激指标的水平。此外，DHA-PS 增加了有益肠道微生物的多样性和丰富度，表明其作为膳食补充剂和功能性食品用于对抗 HFD 诱导的 NAFLD 的潜力。
