Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China.
Zhoushan Institute for Food and Drug Control, Zhoushan, China.
Front Immunol. 2022 May 19;13:916618. doi: 10.3389/fimmu.2022.916618. eCollection 2022.
The effects of fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of and , and inhibiting , , , , and . These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
本研究旨在探讨褐藻糖胶（LF）对环磷酰胺（CTX）处理小鼠免疫调节和肠道微生物群的影响。结果表明，LF 显著提高了脾和胸腺指数，促进了脾淋巴细胞和腹腔巨噬细胞的增殖，并增加了血清中免疫相关细胞因子的产生。此外，LF 可以调节肠道菌群组成，增加 和 的丰度，抑制 、 、 、 、和 的丰度。这些结果与免疫特征呈正相关。总之，LF 可用作减轻 CTX 免疫抑制和肠道微生物群紊乱的新策略。
