Sun Beiqi, Zheng Sihan, Mo Fanyang
School of Materials Science and Engineering, Peking University, Beijing 100871, China.
Chem Commun (Camb). 2021 Jun 8;57(46):5674-5677. doi: 10.1039/d1cc02134f.
We report operationally simple and neutral conditions for borylation of alkyl bromides and iodides to alkyl boronic esters under transition metal- and light-free conditions. A series of substrates with a wide range of functional groups were effectively transformed into the borylation products in moderate to good yields. Mechanistic studies, including radical clock experiments and DFT calculations, gave detailed insight into the radical borylation process.
我们报道了在无过渡金属和无光照条件下，将烷基溴化物和碘化物硼化为烷基硼酸酯的操作简单且中性的条件。一系列具有广泛官能团的底物能有效地转化为硼化产物，产率适中至良好。包括自由基钟实验和密度泛函理论计算在内的机理研究，深入洞察了自由基硼化过程。
