Be The Match Seattle Collection Center, National Marrow Donor Program, Seattle, WA, USA.
Department of Pathology, University of Southern California, Los Angeles, CA, USA.
Am J Clin Pathol. 2021 Oct 13;156(5):818-828. doi: 10.1093/ajcp/aqab028.
To compare the performance of the TEG 5000 and TEG 6S Global Hemostasis cartridge.
We reviewed validation data of the TEG 5000 and TEG 6S Global Hemostasis cartridge. The specimens were analyzed in parallel according to the manufacturer's operating instructions.
Fifty-four healthy donors and 13 donors with known hemostatic abnormalities were included. The correlations between instrument types were only moderate-the Spearman rank correlations were 0.55, 0.62, 0.64, and 0.72, respectively, for CK R, K, angle, and maximum amplitude (MA) parameters. Using the manufacturer's device-specific reference ranges to classify results as normal/abnormal, there was weak agreement in the qualitative interpretation of all parameters (Cohen's κ for agreement for CK R, K, angle, and MA was 0.418, 0.154, -0.083, and 0.127, respectively). This could lead to discordant transfusion decisions.
These findings indicate that the TEG 5000 and TEG 6S may not be used interchangeably.
比较 TEG 5000 和 TEG 6S 全球止血试剂盒的性能。
我们回顾了 TEG 5000 和 TEG 6S 全球止血试剂盒的验证数据。根据制造商的操作说明，同时对标本进行分析。
共纳入 54 名健康供体和 13 名已知止血异常的供体。仪器类型之间的相关性仅为中度-CK R、K、角度和最大振幅（MA）参数的 Spearman 秩相关系数分别为 0.55、0.62、0.64 和 0.72。使用制造商特定的仪器参考范围将结果分类为正常/异常，所有参数的定性解释均存在弱一致性（CK R、K、角度和 MA 的 Cohen's κ 一致性分别为 0.418、0.154、-0.083 和 0.127）。这可能导致输血决策不一致。
这些发现表明 TEG 5000 和 TEG 6S 可能不能互换使用。
