Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
NewYork Presbyterian Hospital, Weill Cornell Medical Campus, New York, NY, USA.
Am J Clin Pathol. 2021 Jul 6;156(2):167-175. doi: 10.1093/ajcp/aqab013.
This review aims to describe the principles underlying different types of inductively coupled plasma mass spectrometry (ICP-MS), and major technical advancements that reduce spectral interferences, as well as their suitability and wide applications in clinical laboratories.
A literature survey was performed to review the technical aspects of ICP-MS, ICP-MS/MS, high-resolution ICP-MS, and their applications in disease diagnosis and monitoring.
Compared to the atomic absorption spectrometry and ICP-optical emission spectrometry, ICP-MS has advantages including improved precision, sensitivity and accuracy, wide linear dynamic range, multielement measurement capability, and ability to perform isotopic analysis. Technical advancements, such as collision/reaction cells, triple quadrupole ICP-MS, and sector-field ICP-MS, have been introduced to improve resolving power and reduce interferences. Cases are discussed that highlight the clinical applications of ICP-MS including determination of toxic elements, quantification of nutritional elements, monitoring elemental deficiency in metabolic disease, and multielement analysis.
This review provides insight on the strategies of elemental analysis in clinical laboratories and demonstrates current and emerging clinical applications of ICP-MS.
本综述旨在描述不同类型电感耦合等离子体质谱（ICP-MS）的基本原理，以及降低光谱干扰的主要技术进展，及其在临床实验室中的适用性和广泛应用。
通过文献调查，回顾了 ICP-MS、ICP-MS/MS、高分辨率 ICP-MS 的技术方面及其在疾病诊断和监测中的应用。
与原子吸收光谱法和 ICP- 发射光谱法相比，ICP-MS 具有提高的精密度、灵敏度和准确性、较宽的线性动态范围、多元素测量能力以及进行同位素分析的能力。已经引入了技术进步，如碰撞/反应池、三重四极杆 ICP-MS 和扇形场 ICP-MS，以提高分辨率并减少干扰。讨论了一些案例，突出了 ICP-MS 的临床应用，包括测定有毒元素、定量营养元素、监测代谢疾病中的元素缺乏以及多元素分析。
本综述提供了临床实验室中元素分析策略的见解，并展示了 ICP-MS 的当前和新兴临床应用。
