Uludag University Faculty of Medicine, Department of Biostatistics, Bursa, Turkey.
Turk Neurosurg. 2021;31(4):618-622. doi: 10.5137/1019-5149.JTN.32785-20.3.
To ascertain whether the brain stem?s shape differs in patients with syrinx and without syrinx in cases with Chiari malformation Type I (CM-1), relative to healthy controls.
Data on marked brainstem regions were obtained from 2D digital image files. Generalized Procrustes analysis was used to evaluate shape differences among patients with syrinx, patients without syrinx, and healthy controls. Shape deformations among groups were examined by Thin Plate Spline (TPS) analysis.
According to the brain stem shape, there were differences between patients with syrinx and controls, and between patients without syrinx and controls. High-level deformations were also observed among the groups.
In the present study, the presence of shape deformations in Chiari patients? brainstem was demonstrated. This is the first study using a landmark-based geometrical morphometric method to demonstrate the shape difference in Chiari patients? brainstem.
确定 Chiari 畸形 I 型（CM-1）患者中，伴有和不伴有脊髓空洞的患者与健康对照组相比，脑干的形状是否存在差异。
从 2D 数字图像文件中获取标记的脑干区域的数据。使用广义 Procrustes 分析评估伴有脊髓空洞、不伴有脊髓空洞的患者和健康对照组之间的形状差异。通过薄板样条（TPS）分析检查各组之间的形状变形。
根据脑干的形状，伴有脊髓空洞的患者与对照组之间存在差异，不伴有脊髓空洞的患者与对照组之间也存在差异。各组之间还观察到高级别变形。
本研究表明，Chiari 患者的脑干存在形状变形。这是首次使用基于标志的几何形态测量方法来证明 Chiari 患者脑干的形状差异。
