Modler S, Kerner J A, Castillo R O, Vreman H J, Stevenson D K
Department of Pediatrics, Stanford University School of Medicine, California 94305.
J Pediatr Gastroenterol Nutr. 1988 Jul-Aug;7(4):554-8. doi: 10.1097/00005176-198807000-00013.
Our study examined the relationship of H2 excreted in breath to total body H2 excreted by neonates. We report simultaneously measured end-tidal H2 concentrations, plus breath H2 and total body H2 (breath H2 plus flatus H2) excretion rates in 10 neonates. End-tidal H2 concentrations varied from 2.4 to 192 ppm. Breath H2 excretion rates ranged from 0.20 to 6.5 and total body H2 excretion rates from 0.29 to 15.0 ml/h. The fractional breath H2 excretion in these infants was 48% (range 33-69%), compared with 21% reported in adults. The correlation coefficient for end-tidal derived H2 excretion and directly measured breath H2 excretion rates was 0.95 (p less than 0.001). We conclude that the proportion of total H2 excreted in the breath of neonates is increased compared with adults, suggesting that caution must be exercised when interpreting newborn breath H2 measurements and using adult norms.
我们的研究检测了呼出气体中氢气（H2）的排出量与新生儿全身氢气排出量之间的关系。我们报告了对10名新生儿同时测量的呼气末氢气浓度，以及呼出氢气和全身氢气（呼出氢气加屁中氢气）的排出率。呼气末氢气浓度在2.4至192 ppm之间变化。呼出氢气排出率在0.20至6.5之间，全身氢气排出率在0.29至15.0 ml/h之间。这些婴儿呼出氢气的排出比例为48%（范围33 - 69%），而成人报告的该比例为21%。呼气末氢气排出量与直接测量的呼出氢气排出率之间的相关系数为0.95（p小于0.001）。我们得出结论，与成人相比，新生儿呼出氢气在总氢气排出量中的比例有所增加，这表明在解读新生儿呼出氢气测量结果并使用成人标准时必须谨慎。
