Tashkin D P, Bresler D E, Kroening R J, Kerschner H, Katz R L, Coulson A
Ann Allergy. 1977 Dec;39(6):379-87.
In a double-blind (patient and evaluator), crossover study effects of real acupuncture, simulated acupuncture, nebulized isoproterenol, nebulized saline and no treatment in reversing methacholine-induced bronchospasm were compared in 12 asthmatics (ages 16 to 64). Saline and simulated acupuncture did not result in any significant improvement in specific airway conductance (SGaw), thoracic gas volume (Vtg) or forced expiratory flow rates compared with no treatment following methacholine-induced bronchospasm. Isoproterenol and real acupuncture were both followed by increases in SGaw and flow rates and decreases in Vtg which were significantly different from the changes observed following no treatment, saline or simulated acupuncture, although isoproterenol produced greater improvement than real acupuncture, although isoproterenol produced greater improvement than real acupuncture. These findings suggest that stimulation of specific acupuncture loci reduces methacholine-induced bronchospasm and hyperinflation to an extent greater than can be attributed to placebo phenomena.
在一项双盲（患者和评估者）交叉研究中，对12名哮喘患者（年龄16至64岁）比较了真正的针灸、模拟针灸、雾化异丙肾上腺素、雾化生理盐水以及不治疗在逆转乙酰甲胆碱诱导的支气管痉挛方面的效果。与乙酰甲胆碱诱导支气管痉挛后不治疗相比，生理盐水和模拟针灸在比气道传导率（SGaw）、胸腔气体容积（Vtg）或用力呼气流量方面未产生任何显著改善。异丙肾上腺素和真正的针灸之后SGaw和流速均增加，Vtg降低，这些变化与不治疗、生理盐水或模拟针灸后观察到的变化显著不同，尽管异丙肾上腺素产生的改善比真正的针灸更大。这些发现表明，刺激特定的针灸穴位可减轻乙酰甲胆碱诱导的支气管痉挛和肺过度充气，其程度大于可归因于安慰剂现象的程度。
