Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Mezzanine Level, C-Wing, PUH 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: https://twitter.com/AkshataMoghe.
Living Donor Liver Transplantation Program, Department of Medicine, University of Pittsburgh Medical Center, Center for Liver Diseases, 3471 Fifth Avenue, 900 Kaufmann Building, Pittsburgh, PA 15213, USA.
Clin Liver Dis. 2021 Feb;25(1):121-135. doi: 10.1016/j.cld.2020.08.011. Epub 2020 Oct 7.
There is an acute shortage of deceased donor organs for liver transplantation in the United States. Nearly a third of patients either die or become too sick for transplant while on the transplant waitlist. Living donor liver transplantation (LDLT) bridges the gap between demand and supply of organs for liver transplantation. This article reviews current living donor selection criteria, and avenues for expansion of criteria with novel surgical techniques and ongoing outcomes research. Ways in which institutions can establish and expand LDLT programs using the Living Donor Champion model are discussed. Efforts to expand recipient indications for LDLT are described.
美国肝移植的已故捐赠者器官严重短缺。近三分之一的患者在等待移植期间死亡或因病情恶化而无法进行移植。活体供肝移植 (LDLT) 弥补了肝移植器官需求和供应之间的差距。本文回顾了当前的活体供者选择标准，并探讨了利用新的外科技术和正在进行的结果研究来扩大标准的途径。讨论了利用活体供者冠军模式建立和扩大 LDLT 项目的机构方法。还描述了扩大 LDLT 受者适应证的努力。
